Erik Jorgensen, Ph.D., Faculty Director
Advanced Microscopy Facility

The Jorgensen lab studies the molecular mechanisms of synaptic transmission using the nematode C. elegans and the mouse, and invests a great deal of effort in the development of new microscopy techniques, both in fluorescence and electron microscopy.   First, the lab was an early adopter of the Bewersdorf bi-plane 3D super-resolution fluorescence microscope; and Vutara Microscopes was a spin-off from the lab. Second, the lab developed a method, called nano-fEM, to quantitatively localize proteins in electron micrographs at 20 nm precision by combining super-resolution microscopy with electron microscopy. Third, the lab pioneered high-pressure freezing methods followed by freeze substitution that preserved morphology for electron microscopy.  Finally, they combined optogenetics with high-pressure freezing and electron microscopy to create a technique known as 'flash-and-freeze’. 'Flash-and-freeze’ allows one to stimulate cells using optogenetics and then freeze them within milliseconds, to generate a frame-by-frame flip book of the synapse at work.

for selected publications on microscopy see:
Jorgenson Lab Publications


David Belnap, Ph.D., Director
Electron Microscopy Core


Chris Rodesch, Ph.D., Director
Fluorescence Microscopy Facility
Research Assistant Professor, Neurobiology and Anatomy
Cell Imaging Core



Mike Redd, Ph.D.
Imaging Specialist